Aspiring model Mary Jane Watson had her life turned upside-down, when she was exposed to the radiation of a strange meteorite. The radiation altered her DNA, enabling her to mimic the powers of insects and arachnids. Deciding that being a superheroine would be much more fun than a model, she assumed the alias of the Insect Queen.
Mary Jane barely began her crime-fighting career when a friend of her parents set her up on a blind date with Spider-Boy. The wild redhead found a kindred spirit in the energetic Spider-Boy, and the two are currently engaged. Unfortunately, Insect Queen's engagement indirectly created her rival Araniella. According to Spider-Boy 2099, Spider-Boy's life would never be the same after he married Insect Queen.
In a possible future, Insect Queen became the mother of Spider-Lass.
Insect Queen has the power to mimic the physical abilities of insects (and some arachnids). If she mimics a hornet, for example, she will sprout insect-like wings and be able to fly, as well as fire bio-electric "stings", if she mimics a bombardier beetle, she can assume its proportionate strength and its ability to fire caustic chemicals, or if she mimics a spider, she can turn her bottom body into spider legs that can stick to walls and an abdomen that can spin webs.
She also has a limited ability to use telepathy to communicate with and command insects.