Aspiring model Mary Jane Watson had her life turned upside-down, when she was exposed to the radiation of a strange meteorite. The radiation altered her DNA, enabling her to mimic the powers of insects and arachnids. Deciding that being a superheroine would be much more fun than a model, she assumed the alias of the Insect Queen.
Mary Jane barely began her crime-fighting career when a friend of her parents set her up on a blind date with Spider-Boy. The wild redhead found a kindred spirit in the energetic Spider-Boy, and the two are currently engaged. Unfortunately, Insect Queen's engagement indirectly created her rival Araniella. According to Spider-Boy 2099, Spider-Boy's life would never be the same after he married Insect Queen.
In a possible future, Insect Queen became the mother of Spider-Lass.
Insect Queen has the power to mimic the physical abilities of insects, including some arachnids:
- By mimicking a hornet, she will sprout insect-like wings for flight and the ability to fire bio-electric "stings".
- By mimicking a bombardier beetle, she will gain proportionate strength and the ability to fire caustic chemicals.
- By mimicking a spider, she can turn her bottom body into spider legs that can stick to walls and an abdomen that can spin webs.
Insect Queen also has limited telepathy, which can be used to communicate with and command insects.