Reed "Prof" Richards was the chief scientist of Project Cadmus and a member of the Challengers of the Fantastic. During the course of his research, he stumbled upon an alternate dimension just beyond his continuum called Universe-Two (U-2).
Prof was once afflicted with "evil" DNA that rival scientist Dabney Donovan had been secretly adding to his diet. Not in control of himself, he freed Bizarnage from Cadmus' menagerie in an act of sabotage. Luckily, Prof was eventually rehabilitated when June Masters cured him of the evil DNA.
Prof is currently working on a device that will control Four-Armed Thing's transformation powers.